NRDR Inhibits the Migration of Endometrial Cancer Cells and Affects Their Gene Expression.

ABSTRACT: Introduction: Studying the pathogenesis of endometrial cancer is important to treatment of endometrial cancer. NADP(H)-dependent retinol dehydrogenase/reductase (NRDR) is associated with the development of cancer. Our previous research has found that NRDR can inhibit the synthesis of estradiol (E2) in granulosa cells. Based on the above statement, we speculate that NRDR may also be involved in the development of endometrial cancer. Therefore, this study investigated the expression patterns and mechanisms of NRDR in endometrial cancer. Material and Methods: This study was performed using Ishikawa cells combined with multiple methods, including immunohistochemical staining, wound healing and Transwell migration assays, RNA-seq analysis, and so on. Results: The results sh

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12259335 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature