Exploring the Chemical Profile, Antioxidants, and Anti-Diabetic Properties of Coffee Beans From Selected East African Countries: A Comparative In Vitro and Computational Study.

ABSTRACT: East Africa, the origin of coffee beans, is renowned for its coffee's cultural significance and potential health benefits, particularly in mitigating metabolic disorders and their related complications. Despite this, studies that comprehensively evaluate their pharmacological potential remain limited. This study investigated the antioxidant and antidiabetic properties of coffee beans from Uganda, Burundi, and Tanzania using in vitro and computational methods. Antioxidant activities were evaluated via DPPH, FRAP, and nitric oxide (NO) assays, while antidiabetic potential was assessed using α-glucosidase and α-amylase inhibitiory assays. Liquid chromatography-mass spectrometry (LC-MS) was employed to screen and identify the phytochemical compounds in the coffee beans. Additionally, computati

SUBMITTER: Mohamed AI 

PROVIDER: S-EPMC12259390 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature