Brain functional connectivity changes in amyotrophic lateral sclerosis with apathy and depression.

ABSTRACT:

Background

Apathy and depression are the most prevalent neuropsychiatric symptoms in amyotrophic lateral sclerosis (ALS). Although insufficiently investigated, their distinction holds important clinical relevance for accurate diagnosis of ALS with behavioural impairment and for patients' prognosis and management. In the present study, we aimed to assess both apathy and depressive symptoms in patients with ALS and whether they have similar or different functional neural correlates.

Methods

Using graph analysis and connectomics, global and lobar nodal properties and regional functional brain connectivity were assessed in ALS patients without apathy/depression (ALSn, n = 42), with apathy without depression (ALSa, n = 14), with depressive symptoms without apathy (ALSd, n = 20),

SUBMITTER: Castelnovo V 

PROVIDER: S-EPMC12259760 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature