A novel electrochemical immunosensor based on biomaterials for detecting carcinoembryonic antigen biomarker in serum samples.

ABSTRACT: A new label-free electrochemical immunosensor was developed to detect carcinoembryonic antigen (CEA), a key diagnostic biomarker for various cancers. The surface of a glassy carbon electrode (GCE) was modified using a layer-by-layer assembly method incorporating sodium alginate (SA), gold nanoparticles (AuNPs), and gamma-manganese dioxide/chitosan (γ.MnO₂-CS). This modification enhanced the functional surface area and electrode conductivity, thereby improving the electrochemical response and sensitivity for CEA detection. Methods including cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used to evaluate the immunosensor`s performance.The sensor quantified CEA concentrations in serum samples by monitoring current variations at the oxidation peak, resulting from the for

SUBMITTER: Sobhanparast S 

PROVIDER: S-EPMC12259841 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature