The Helicobacter pylori AI-clinician harnesses artificial intelligence to personalise H. pylori treatment recommendations.

ABSTRACT: Helicobacter pylori (H. pylori) is the most common carcinogenic pathogen globally and the leading cause of gastric cancer. Here, we develop a reinforcement learning-based AI Clinician system to personalise treatment selection and evaluate its ability to improve eradication success compared to clinician-prescribed therapies. The model is trained and internally validated on 38,049 patients from the retrospective European Registry on Helicobacter pylori Management (Hp-EuReg), using independent state deep Q-learning (isDQN) to recommend optimal therapies based on patient characteristics such as age, sex, antibiotic allergies, country, and pre-treatment indication. In internal validation using real-world Hp-EuReg data, AI-recommended therapies achieve a 94.1% success rate (95% CI: 93.2-95.0%) v

SUBMITTER: Higgins K 

PROVIDER: S-EPMC12259899 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature