Elucidating the high compliance mechanism by which the urinary bladder fills under low pressures.

ABSTRACT: The high compliance of the urinary bladder during filling is essential for its proper function, enabling it to accommodate significant volumetric increases with minimal rise in transmural pressure. This study aimed to elucidate the physical mechanisms underlying this phenomenon by analyzing the ex vivo filling process in rat from a fully voided state to complete distension, without preconditioning, using three complementary imaging modalities. High-resolution micro-CT at 10.8 [Formula: see text]m resolution was used to generate detailed 3D reconstructions of the bladder lumen, revealing an average 62-fold increase in bladder volume during filling. Pressure-volume studies of whole bladder delineated three mechanical filling regimes: an initial high-compliance phase, a transitional phase, an

SUBMITTER: Azari F 

PROVIDER: S-EPMC12259916 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature