Phenotypic screening and genetic insights for predicting major vascular-related diseases using retinal imaging.

ABSTRACT: Retinal photography is a valuable non-invasive tool for assessing vascular health, but genetic evidence linking retinal microcirculation to major vascular-related diseases (e.g., myocardial infarction [MI], stroke, and chronic kidney disease [CKD]) remains scarce. This study investigates their relationships from both phenotypic and genetic perspectives. Phenotypically, we developed a retinal imaging-based screening model to evaluate 10-year risk of these conditions, incorporating quantitative analyses to pinpoint specific vascular abnormalities. Genetically, we analyzed retinal image-derived traits to explore their genetic and causal relationships with vascular-related diseases. Internal validation with 25,840 UK Biobank participants and external temporal validation with 4558 participants

SUBMITTER: Lu M 

PROVIDER: S-EPMC12259969 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature