Educational attainment, electroencephalographic rhythms, cortical structure, and cognitive performance over 2 years in older adults with subjective memory complaints and brain amyloidosis.

ABSTRACT:

Introduction

We investigated whether older adults with subjective memory complaints (SMC) and amyloid-β accumulation may show clinical progression over 2 years, as measured by resting-state electroencephalographic (rsEEG), structural magnetic resonance imaging (sMRI), and cognitive variables, depending on educational attainment.

Methods

We analyzed these markers in 84 SMC participants from INSIGHT-Pre-AD study, grouped by amyloid-β deposition (¹⁸F-florbetapir positron emission tomography) and educational attainment.

Results

In amyloid-negative individuals, higher educational attainment was linked to greater posterior rsEEG alpha activity, possibly reflecting neuroprotective effects. Conversely, amyloid-positive individuals with higher educational attainment

SUBMITTER: Lopez S 

PROVIDER: S-EPMC12260118 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature