Cardiorespiratory fitness modifies the relationship between arterial stiffness and cerebral blood flow independent of physical activity.

ABSTRACT:

Introduction

Central arterial stiffness and cerebral blood flow (CBF) are inversely related. Poor cardiorespiratory fitness (CRF) and low physical activity (PA) are related to both higher arterial stiffness and lower CBF. The present study examined (i) whether CRF or PA moderate the relationship between arterial stiffness and CBF, and (ii) whether the intensity or the type of PA needs to be considered.

Methods

Participants (N = 78, Mean_AGE = 64.2±6.14, 72% female) from the Wisconsin Registry for Alzheimer's Prevention and the Wisconsin Alzheimer's Disease Research Center were categorized into low, average, and high fitness groups based on maximal graded exercise treadmill test performance. PA was assessed using the CHAMPS (Community Health Activities Model

SUBMITTER: Breidenbach BM 

PROVIDER: S-EPMC12260121 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature