Associations between mid-life social relationships and the risk of incident dementia: The ARIC study.

ABSTRACT:

Introduction

This study aimed to assess whether mid-life social relationships are associated with a lower risk of late-life dementia.

Methods

Participants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (Visit 2;1990-1992). A composite measure, "social relationships," was generated. Incident dementia cases were identified following Visit 2 through 2019, using ongoing surveillance. Associations between mid-life social relationships and incident dementia were evaluated with Cox proportional-hazard regression models. Formal interaction tests examined whether sex or race modified this association.

Results

Among 13,070 participants without dementia, those with strong social relationships in mid-life had a lower risk fo

SUBMITTER: Groechel RC 

PROVIDER: S-EPMC12260128 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature