Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height.

ABSTRACT: Genomewide linkage analysis has been extremely successful at identification of the genetic variation underlying single-gene disorders. However, linkage analysis has been less successful for common human diseases and other complex traits in which multiple genetic and environmental factors interact to influence disease risk. We hypothesized that a highly heritable complex trait, in which the contribution of environmental factors was relatively limited, might be more amenable to linkage analysis. We therefore chose to study stature (adult height), for which heritability is approximately 75%-90% (Phillips and Matheny 1990; Carmichael and McGue 1995; Preece 1996; Silventoinen et al. 2000). We reanalyzed genomewide scans from four populations for which genotype and height data were available, us

SUBMITTER: Hirschhorn JN 

PROVIDER: S-EPMC1226025 | biostudies-literature | 2001 Jul

REPOSITORIES: biostudies-literature