A genome screen of families with multiple cases of prostate cancer: evidence of genetic heterogeneity.

ABSTRACT: We conducted a genomewide screen for prostate cancer-susceptibility genes on the basis of data from 98 families from the United States and Canada that had three or more verified diagnoses of prostate cancer among first- and second-degree relatives. We found a statistically significant excess of markers for which affected relatives exhibited modest amounts of excess allele-sharing; however, no single chromosomal region contained markers with excess allele-sharing of sufficient magnitude to indicate unequivocal evidence of linkage. Positive linkage signals of nominal statistical significance were found in two regions (5p-q and 12p) that have been identified as weakly positive in other data sets and in region 19p, which has not been identified previously. All these signals were considerably s

SUBMITTER: Hsieh CL 

PROVIDER: S-EPMC1226029 | biostudies-literature | 2001 Jul

REPOSITORIES: biostudies-literature