Resolvin D1-mediated cellular crosstalk protects against MASH.

ABSTRACT:

Background & aims

Recent studies have highlighted the beneficial effect of resolvin D1 (RvD1), a docosahexaenoic acid-derived specialized pro-resolving mediator, on chronic liver diseases, but the underlying mechanisms are not well understood. Our study aimed to determine the role and mechanism of RvD1-mediated cellular crosstalk in metabolic dysfunction-associated steatohepatitis (MASH).

Methods

RvD1 was administered to mice with experimental MASH, followed by bulk and single cell RNA sequencing (scRNA-seq) analysis. Primary liver cells, including primary hepatocytes, Kupffer cells (KCs), T cells, and hepatic stellate cells (HSCs), were isolated for co-culture experiments to elucidate the effect of RvD1 on cell death, inflammation, and fibrosis.

Results

Hepatic tissu

SUBMITTER: Navarro-Corcuera A 

PROVIDER: S-EPMC12260426 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature