Model-free linkage analysis with covariates confirms linkage of prostate cancer to chromosomes 1 and 4.

ABSTRACT: As with many complex genetic diseases, genome scans for prostate cancer have given conflicting results, often failing to provide replication of previous findings. One factor contributing to the lack of consistency across studies is locus heterogeneity, which can weaken or even eliminate evidence for linkage that is present only in a subset of families. Currently, most analyses either fail to account for locus heterogeneity or attempt to account for it only by partitioning data sets into smaller and smaller portions. In the present study, we model locus heterogeneity among affected sib pairs with prostate cancer by including covariates in the linkage analysis that serve as surrogate measures of between-family linkage differences. The model is a modification of the Olson conditional logistic

SUBMITTER: Goddard KA 

PROVIDER: S-EPMC1226100 | biostudies-literature | 2001 May

REPOSITORIES: biostudies-literature