Expression of PDZ domain-containing proteins is correlated with prognosis and immune infiltration in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC)-a predominant type of primary liver cancer-poses a significant global health threat with high incidence and mortality rates. Despite advances in treatment modalities, including surgery, chemotherapy, and immunotherapy, HCC exhibits high relapse rates and low long-term survival, necessitating the identification of novel prognostic markers and treatment targets. This study aims to develop a prognostic model centered on the PDZ domain by identifying key PDZ proteins associated with HCC through bioinformatics analysis of large-scale public datasets, in order to improve prognosis prediction and inform therapeutic strategies.

Methods

Differentially expressed PDZ proteins (DEPs) in HCC were identified through RNA sequencing (RNA-seq) analys

SUBMITTER: Song X 

PROVIDER: S-EPMC12261004 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature