Trends in Atrial Fibrillation-Related Mortality Among Older Adults With Obstructive Sleep Apnea in the United States, 1999-2020.

ABSTRACT:

Background

Atrial fibrillation (AF) and obstructive sleep apnea (OSA) frequently coexist and synergistically increase cardiovascular risk. While their pathophysiologic interplay is well established, national data on mortality trends involving both conditions are scarce.

Methods

We analyzed mortality data from the CDC WONDER platform (1999-2020), including adults aged ≥ 25 years with AF (ICD-10 I48.x) listed as the underlying cause of death and OSA (G47.33) as a contributing condition. Age-adjusted mortality rates (AAMRs) and average annual percent changes (AAPCs) were calculated using Joinpoint regression, stratified by sex, race/ethnicity, urbanization, region, and age.

Results

A total of 32,142 AF-related deaths with OSA were identified. The overall AAMR was 0.60 pe

SUBMITTER: Hassan IN 

PROVIDER: S-EPMC12261039 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature