Comparison of catheter wound infusion, intrathecal morphine, and intravenous analgesia for postoperative pain management in open liver resection: randomized clinical trial.

ABSTRACT:

Background

Pain relief is an important aspect of recovery after open liver resection. This randomized open-label single-centre trial assessed the efficacy of intravenous (i.v.) analgesia alone or in combination with catheter wound infusion (CWI) or intrathecal morphine (ITM) after open liver resection.

Methods

Adult patients undergoing open liver resection were randomly assigned to receive either i.v. analgesia alone or in combination with ITM or CWI. In this study, i.v. analgesia consisted of systematic i.v. paracetamol and i.v. morphine via a patient-controlled analgesia pump, with i.v. nefopam as rescue analgesia for a Numeric Rating Scale (NRS) score > 4. The primary outcome was cumulative morphine dose at 24 hours (h). Secondary outcomes included pain intensity, cumulat

SUBMITTER: Rousseleau D 

PROVIDER: S-EPMC12261295 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature