Interactions between Ploidy and Resource Availability Shape Clonal Evolution in Glioblastoma.

ABSTRACT: Glioblastoma (GBM) is the most aggressive form of primary brain tumor. The infiltrative nature of GBM makes complete surgical resection impossible. The selective forces that govern gliomagenesis are strong, shaping the composition of tumor cells during the initial progression to malignancy with late consequences for invasiveness and therapy response. Here, we developed a mathematical model that incorporates ploidy level and the nature of the brain tissue microenvironment to simulate the growth and invasion of GBM and used the model to make inferences about GBM initiation and response to the standard-of-care treatment. The spatial distribution of resource access in the brain was approximated through integration of in silico modeling, multiomics data, and image analysis of primary and recurr

SUBMITTER: Nowicka Z 

PROVIDER: S-EPMC12261341 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature