GASTON-Mix: a unified model of spatial gradients and domains using spatial mixture-of-experts.

ABSTRACT:

Motivation

Gene expression varies across a tissue due to both the organization of the tissue into spatial domains, i.e. discrete regions of a tissue with distinct cell type composition, and continuous spatial gradients of gene expression within different spatial domains. Spatially resolved transcriptomics (SRT) technologies provide high-throughput measurements of gene expression in a tissue slice, enabling the characterization of spatial gradients and domains. However, existing computational methods for quantifying spatial variation in gene expression either model only spatial domains-and do not account for continuous gradients of expression-or require restrictive geometric assumptions on the spatial domains and spatial gradients that do not hold for many complex tissues.

Result

SUBMITTER: Chitra U 

PROVIDER: S-EPMC12261403 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature