ScGOclust: leveraging gene ontology to find functionally analogous cell types between distant species.

ABSTRACT:

Motivation

Basic biological processes are shared across animal species, yet their cellular mechanisms are profoundly diverse. Comparing cell-type gene expression between species reveals conserved and divergent cellular functions. However, as phylogenetic distance increases, gene-based comparisons become less informative. The gene ontology (GO) knowledgebase offers a solution by serving as the most comprehensive resource of gene functions across a vast diversity of species, providing a bridge for distant species comparisons.

Results

Here, we present scGOclust, a computational tool that constructs de novo cellular functional profiles using GO terms, facilitating systematic and robust comparisons within and across species. We applied scGOclust to analyse and compare the heart,

SUBMITTER: Song Y 

PROVIDER: S-EPMC12261464 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature