Recomb-Mix: fast and accurate local ancestry inference.

ABSTRACT:

Motivation

The availability of large genotyped cohorts brings new opportunities for revealing the high-resolution genetic structure of admixed populations via local ancestry inference (LAI), the process of identifying the ancestry of each segment of an individual haplotype. Though current methods achieve high accuracy in standard cases, LAI is still challenging when reference populations are more similar (e.g. intra-continental), when the number of reference populations is too numerous, or when the admixture events are deep in time, all of which are increasingly unavoidable in large biobanks.

Results

In this work, we present Recomb-Mix, a new LAI method which integrates elements from the site-based Li and Stephens model and introduces a new graph collapsing techniques to sim

SUBMITTER: Wei Y 

PROVIDER: S-EPMC12261469 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature