LoRA-DR-suite: adapted embeddings predict intrinsic and soft disorder from protein sequences.

ABSTRACT:

Motivation

Intrinsic disorder regions (IDR) and soft disorder regions (SDR) provide crucial information on a protein structure to underpin its functioning, interaction with other molecules and assembly path. Circular dichroism experiments are used to identify intrinsic disorder residues, while SDRs are characterized using B-factors, missing residues, or a combination of both in alternative X-ray crystal structures of the same molecule. These flexible regions in proteins are particularly significant in diverse biological processes and are often implicated in pathological conditions. Accurate computational prediction of these disordered regions is thus essential for advancing protein research and understanding their functional implications.

Results

LoRA-DR-suite addresses the

SUBMITTER: Lombardi G 

PROVIDER: S-EPMC12261480 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature