Recovering time-varying networks from single-cell data.

ABSTRACT:

Motivation

Gene regulation is a dynamic process that underlies all aspects of human development, disease response, and other biological processes. The reconstruction of temporal gene regulatory networks has conventionally relied on regression analysis, graphical models, or other types of relevance networks. With the large increase in time series single-cell data, new approaches are needed to address the unique scale and nature of these data for reconstructing such networks.

Results

Here, we develop a deep neural network, Marlene, to infer dynamic graphs from time series single-cell gene expression data. Marlene constructs directed gene networks using a self-attention mechanism where the weights evolve over time using recurrent units. By employing meta learning, the model is

SUBMITTER: Hasanaj E 

PROVIDER: S-EPMC12261490 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature