The prognostic value of lactate dehydrogenase/albumin ratio in extranodal natural killer/T cell lymphoma.

ABSTRACT:

Objective

Extranodal natural killer/T-cell lymphoma (ENKTL) is recognized for its aggressive nature and variable clinical presentation, often leading to a poor prognosis. While the combined assessment of baseline serum lactate dehydrogenase (LDH) and albumin (ALB) levels has demonstrated prognostic value across various malignancies, its specific application and evidence in ENKTL are unstudied.

Purpose

This study aimed to investigate the impact of the lactate dehydrogenase/albumin ratio (LAR) in ENKTL, offering nutritional and immunological insights to enhance risk stratification.

Results

We conducted a retrospective analysis of 484 ENKTL patients treated with asparaginase-based regimens. The optimal thresholds for serum LDH and ALB levels were identified as 230 u/L an

SUBMITTER: Li N 

PROVIDER: S-EPMC12261561 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature