Age-targeted vaccination for reducing Clostridioides difficile infection in England: a coupled mathematical-economic modelling analysis.

ABSTRACT:

Background

Clostridioides difficile infection (CDI) is associated with high morbidity and mortality, emphasising the need for prophylaxis. The lead vaccine candidate recently demonstrated promising reductions in medically attended cases.

Methods

Key risk factors for CDI were incorporated into a hospital-level mathematical model used to simulate the impact of the vaccine on reducing disease burden in England. Model outputs of interest included medically attended cases, intensive care admissions and deaths associated with CDI, as well as costs and quality-adjusted life years (QALYs). Hospital costs and costs of years of life lost due to premature mortality averted per vaccine course were computed for a 10-year time horizon.

Results

The epidemiological model demonstrated

SUBMITTER: Yakob L 

PROVIDER: S-EPMC12261565 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature