Whole transcriptome sequencing to uncover CircRNA expression patterns linked to schizophrenia pathogenesis.

ABSTRACT:

Background

No objective diagnostic indicators have been identified for schizophrenia (SCZ) because of the complexity of its pathogenesis. Whole-transcriptome analysis may help identify early diagnostic markers. While circular RNAs (circRNAs) have been reported to be involved in the onset and development of many diseases, their association with SCZ remains unclear.

Methods

This case‒control study analysed 5 pairs of peripheral blood samples from SCZ patients and controls. The samples were subjected to whole transcriptome analysis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were subsequently performed to identify the biological functions and pathways of the circRNAs. The competing endogenous RNA (ceRNA) network was predicted via miRanda, Tar

SUBMITTER: Long J 

PROVIDER: S-EPMC12261635 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature