Cool temperature inhibits binary fission and results in phenotypic and transcriptomic changes that suggest inducible aging in Diadumene lineata.

ABSTRACT:

Objective

Here we report initial observations and bioinformatics analysis suggesting that the sea anemone Diadumene lineata can be induced to age when cultured at 16^oC. Inducible aging may make D. lineata a useful experimental model for aging studies. This research stemmed from a published study of D. lineata that did not involve or report on inducible aging.

Results

Anemones cultured at 16^oC displayed several signs of aging not evident when cultured at room temperature (21^oC), including the cessation of binary fission, growth to a much larger size, a progressive reduction in the consumption of prey, and ultimately, shriveling. Re-analysis of published RNA-seq data identified 2,824 differentially expressed putative genes in anemones cultured

SUBMITTER: Makamure CE 

PROVIDER: S-EPMC12261649 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature