P38 mitogen-activated protein kinase drives senescence in CD4⁺ T lymphocytes and increases their pathological potential.

ABSTRACT:

Background

In several diseases, senescent T lymphocytes increase in number and release a senescence-associated secretory phenotype (SASP) with inflammatory and osteoclastogenic potential, favoring inflammation and bone loss. It is well known that the activation of p38 mitogen-activated protein kinase (p38 MAPK) orchestrates senescence in CD8⁺ T lymphocytes. However, p38 MAPK contribution to CD4⁺ T lymphocyte senescence remains less comprehensively characterized and warrants further investigation. This study investigates the contribution of p38 MAPK to senescence in CD4⁺ T lymphocytes, focusing on mitochondrial dysfunction and SASP production to elucidate their pathological potential.

Results

Splenic CD4⁺ T lymphocytes isolated from

SUBMITTER: Gonzalez-Osuna L 

PROVIDER: S-EPMC12261694 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature