Promoter demethylation of cerebellin 2 by ten-eleven translocation 3 contributes to peripheral sensitization in trigeminal neuropathic pain of mice.

ABSTRACT:

Background

Chronic neuropathic pain involves complex molecular adaptations, and emerging evidence indicates that cerebellins (CBLNs) play a role in sensory processing. This study investigates the role of CBLN2 in trigeminal neuropathic pain (TNP) and examines its regulation through epigenetic mechanisms.

Methods

Bioinformatics analyses of CBLNs were performed using publicly available expression data from the trigeminal ganglion (TG). A mouse model of TNP was established through partial infraorbital nerve transection (pIONT). Facial allodynia in mice was assessed using the von Frey test. Quantitative real-time PCR (qRT-PCR), Western blotting and enzyme-linked immunosorbent assay (ELISA) were performed to evaluate the expression of CBLN2. Immunofluorescence was used to determi

SUBMITTER: Guan XY 

PROVIDER: S-EPMC12261730 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature