The tumour sink effect on ⁶⁸Ga-PSMA-PET/CT in metastatic castration-resistant prostate cancer and its implications for PSMA-RPT: a sub-analysis of the 3TMPO study.

ABSTRACT:

Background

The tumour sink effect is a phenomenon whereby the sequestration of a radiopharmaceutical in cancer lesions leads to decreased activity concentration in the blood stream and organs. The aim of this sub-analysis of the prospective 3TMPO study (NCT04000776) was to investigate the tumour sink effect on prostate-specific membrane antigen (PSMA) PET imaging in a population of patients with metastatic castration-resistant prostate cancer (mCRPC).

Methods

Ninety-seven participants underwent ⁶⁸Ga-PSMA-617 PET/CT imaging. The activity concentration in the kidney, parotid, spleen, liver and blood was expressed as a percentage of injected activity per cubic centimetre (%IA/cm³). The total tumour volume was delineated, and the total lesion fraction (TLF)

SUBMITTER: Zamanian A 

PROVIDER: S-EPMC12261768 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature