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ABSTRACT: Background
Frailty is a significant clinical syndrome affecting aging populations, leading to increased risks of negative outcomes such as falls, disability, hospitalization, and premature mortality. The concept has evolved from a simplistic view to a complex view that incorporates physical, psychological, cognitive, and social domains. Early intervention is crucial, yet research on the interactions among these domains is limited. This study protocol aims to outline various combinations of biological, psychosocial and nutritional interventions in prefrail older adults to address their effects on frailty status, including physical, psychological, and social functioning, nutritional status, and lifestyle changes over a 9-month intervention and follow-up period.Methods
This st
SUBMITTER: Jiao J
PROVIDER: S-EPMC12261824 | biostudies-literature | 2025 Jul
REPOSITORIES: biostudies-literature