Ontology highlight
ABSTRACT:
SUBMITTER: Hillmer AM
PROVIDER: S-EPMC1226186 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
American journal of human genetics 20050518 1
Androgenetic alopecia (AGA), or male-pattern baldness, is the most common form of hair loss. Its pathogenesis is androgen dependent, and genetic predisposition is the major requirement for the phenotype. We demonstrate that genetic variability in the androgen receptor gene (AR) is the cardinal prerequisite for the development of early-onset AGA, with an etiological fraction of 0.46. The investigation of a large number of genetic variants covering the AR locus suggests that a polyglycine-encoding ...[more]