The germline coordinates mitokine signaling.

ABSTRACT: The ability of mitochondria to coordinate stress responses across tissues is critical for health. In C. elegans, neurons experiencing mitochondrial stress elicit an inter-tissue signaling pathway through the release of mitokine signals, such as serotonin or the Wnt ligand EGL-20, which activate the mitochondrial unfolded protein response (UPR^MT) in the periphery to promote organismal health and lifespan. We find that germline mitochondria play a surprising role in neuron-to-periphery UPR^MT signaling. Specifically, we find that germline mitochondria signal downstream of neuronal mitokines, Wnt and serotonin, and upstream of lipid metabolic pathways in the periphery to regulate UPR^MT activation. We also find that the germline tissue itself is essential for UP

SUBMITTER: Shen K 

PROVIDER: S-EPMC12261959 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature