Neuromodulatory influences on propagation of traveling waves along the unimodal-transmodal gradient.

ABSTRACT: Understanding the factors underlying brain activity fluctuation is important to understand the flexible nature of the brain and cognition. Growing evidence indicates that functional magnetic resonance imaging (fMRI) activity travels as waves around global signal peaks following a unimodal-transmodal gradient. This may explain the organization of brain activity into functional networks, but why the strength of integration between networks fluctuates is uncertain. Given that arousal-related neuromodulatory systems affect network integration and that traveling waves are modulated by arousal, we aimed to assess the hypothesis that an increase in neuromodulatory tone can affect network integration by modulating the speed of propagation of traveling waves. We tested this hypothesis using pharmac

SUBMITTER: Maki-Marttunen V 

PROVIDER: S-EPMC12262121 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature