Fluidic Programmable Gravi-maze Array for High Throughput Multiorgan Drug Testing.

ABSTRACT: The high attrition rate of drug candidates in clinical trials underscores the urgent need for more predictive preclinical models that accurately replicate human physiology. Traditional two-dimensional (2D) cell cultures and animal models often fail to predict human responses due to their limited physiological relevance. This highlights the need for modeling and measurements of multiorgan interactions at higher throughput prompting the development of multiorgan-on-a-plate (MOAP) platforms. Here, we present OrganRX^™, a modular, gravity-driven recirculation-based MOAP system designed to imitate human organ function, fluid dynamics, and inter-organ communication in vitro. The platform based on Fluidic Programmable Gravi-maze Array (FPGA) integrates multiple organ types-gut, liver, k

SUBMITTER: Wong HC 

PROVIDER: S-EPMC12262207 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature