Climbing fibers selectively recruit disinhibitory interneurons to enhance dendritic calcium signaling in cerebellar Purkinje cells.

ABSTRACT: Climbing fiber (CF) inputs to Purkinje cells (PCs) instruct plasticity and learning in the cerebellum^1-3. Paradoxically, CFs also excite molecular layer interneurons (MLIs)^4,5, a cell-type that inhibits PCs and can restrict plasticity and learning^6,7. However, two types of MLIs with opposing influences have recently been identified: MLI1s inhibit PCs, reduce dendritic calcium signals, and suppress plasticity of granule cell to PC synapses^2,6-9, whereas MLI2s inhibit MLI1s and disinhibit PCs⁸. To determine how CFs can activate MLIs without also suppressing the PC calcium signals necessary for plasticity and learning, we investigated the specificity of CF inputs onto MLIs. Serial EM reconstructions indicate that CFs contact both MLI subt

SUBMITTER: Santos-Valencia F 

PROVIDER: S-EPMC12262208 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature