Growth Arrest of Thoracic Aortic Aneurysms in Aging Marfan Mice.

ABSTRACT: There is a pressing need to identify pathologic mechanisms that render a thoracic aortic aneurysm susceptible to continued enlargement, dissection, or rupture, but additional insight can be gleaned by understanding potential compensatory mechanisms that prevent disease progression and thereby stabilize a lesion. Our biomechanical data suggest that the ascending aorta within a common mouse model of Marfan syndrome, Fbn1 ^C1041G/+, exhibits progressive disease from 12 weeks to 1 year of age, but near growth arrest from 1 to 2 years of age. Comparison of the biomechanical phenotype, histological characteristics, proteomic signature, and transcriptional profile from 12 weeks to 1 year to 2 years suggests that numerous differentially expressed genes (including downregula

SUBMITTER: Weiss D 

PROVIDER: S-EPMC12262233 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature