Four neurons pattern brain-wide developmental activity through neuropeptide signaling.

ABSTRACT: The developing brain becomes electrically active before it is ready to process sensory input. During neural circuit maturation, developmental activity is thought to refine synaptic connections by driving neuronal co-activation in rhythmic patterns. The source of this brainwide activity and the mechanisms which regulate its patterns are not well understood. Here we describe cellular interactions that shape developmental activity and their molecular basis. In Drosophila, patterned stimulus independent neural activity (PSINA) engages the entire brain in highly stereotyped, globally coordinated cycles of activity. A molecularly-defined population of ~2,000 neurons (Transient Receptor Potential Gamma, Trpγ+ neurons) act as an activity template for PSINA. We show that this activity

SUBMITTER: Reichl J 

PROVIDER: S-EPMC12262248 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature