Paracrine Action of Bone Morphogenetic Protein 3 in Pulmonary Arterial Hypertension.

ABSTRACT:

Background

Despite recent advancements in the management of pulmonary arterial hypertension (PAH), the disease remains devastating, with limited survival. Although the Bone Morphogenetic Protein (BMP) signaling pathway is known to play an important role in PAH, our current understanding of this pathway remains limited.

Methods

We assessed BMP3 levels in the lungs of mice, rats, and pigs with pulmonary hypertension, and in pulmonary vascular cells from human patients with PAH. We performed in vitro studies on human pulmonary artery smooth muscle cells (hPASMCs) and human pulmonary artery endothelial cells (hPAECs) derived from healthy donors and from patients with PAH. We generated mice with global or SMC-specific deletion of BMP3. Recombinant BMP3 protein and adeno-associate

SUBMITTER: Halouani A 

PROVIDER: S-EPMC12262296 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature