Light and temperature sensitive seizures are regulated by spatially distinct cortex glial populations in the central nervous system.

ABSTRACT: Epilepsy is a brain disorder, characterized by recurrent seizures due to abnormal neuronal activity originating from a population of cortical neurons. It is known that seizures are often associated with abnormal glial cell function at the seizure focus. Recent studies have shown that each glial type such as astrocytes display significant degree of heterogeneity in their development, molecular signatures, and function depending on the brain region in which they are located. It is unknown if such heterogeneity differentially influence/cause seizures. Previous studies in Drosophila have shown that aberrant cortex glial function led to light inducible seizures in Ceramide phosphoethanolamine synthase (cpes) and temperature inducible seizures in zyd mutants. Here, we have optimized Gal4/Split-G

SUBMITTER: Kunduri G 

PROVIDER: S-EPMC12262350 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature