The human claustrum initiates networks for externally and internally driven task demands.

ABSTRACT: Cognitive control is believed to arise from interactions among multiple brain networks depending on task demands. Although several debilitating neuropsychiatric disorders are characterized by cognitive network dysfunction, the neural circuit mechanisms supporting task-dependent network activation are largely unknown. Because the claustrum possesses widespread connections with cortex and can synchronize distant cortical regions, we tested whether the claustrum activates task-dependent network states using fMRI during working memory (n = 420) and autobiographical memory (n = 35), tasks which elicit opposing responses from key cognitive control networks. In both tasks, the claustrum exhibited increased activity and excitatory influence on task-associated cognitive control networ

SUBMITTER: Stewart BW 

PROVIDER: S-EPMC12262355 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature