Disrupted Energy Landscape in Individuals with Mild Cognitive Impairment: Insights from Network Control Theory.

ABSTRACT:

Introduction

Patients with mild cognitive impairment (MCI) have shown disruptions in both brain structure and function, often studied separately. However, understanding the relationship between brain structure and function can provide valuable insights into this early stage of cognitive decline for better treatment strategies to avoid its progression. Network Control Theory (NCT) is a multi-modal approach that captures the alterations in the brain's energetic landscape by combining the brain's functional activity and the structural connectome. Our study aims to explore the differences in the brain's energetic landscape between people with MCI and healthy controls (HC).

Methods

Four hundred ninety-nine HC and 55 MCI patients were included. First, k-means was applied to functi

SUBMITTER: Neumann D 

PROVIDER: S-EPMC12262368 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature