Epilogos: information-theoretic navigation of multi-tissue functional genomic annotations.

ABSTRACT: Functional genomics data, such as chromatin state maps, provide critical insights into biological processes, but are hard to navigate and interpret. We present Epilogos to address this challenge by offering a simple information-theoretic framework for large-scale visualization, navigation and interpretation of functional genomics annotations, and apply it to over 2,000 genome-wide chromatin state maps in human and mouse. We construct intuitive visualizations of multi-tissue chromatin state maps, prioritize salient genomic regions, identify group-wise differential regions, and enable rapid similarity search given a region of interest. To facilitate usability, we provide a purpose-built web-based browser interface (http://epilogos.net) alongside open-source software for community access and

SUBMITTER: Quon J 

PROVIDER: S-EPMC12262391 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature