Tre-DST: A new drug susceptibility test for <i>Mycobacterium tuberculosis</i> using solvatochromic trehalose probes.

ABSTRACT: Tuberculosis (TB) is the most lethal cause of death from a single infectious agent. In 2024, an estimated 10 million people developed TB, nearly half a million of which were infected with drug-resistant tuberculosis (DR-TB). Early detection of infection and drug resistance is critical to controlling DR-TB as this enables rapid engagement into effective care. Currently, bacterial culture and nucleic acid testing remain the primary methods for diagnosing infection, with smear microscopy being phased out. However, these methods present significant limitations for diagnosing drug resistance such as lengthy time-to-result for phenotypic tests, as well as the need for prior knowledge of resistance mutations and prohibitive cost for molecular tests. To address this, we developed a rapid phenotypi

SUBMITTER: Schwartz LA 

PROVIDER: S-EPMC12262397 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature