Cellular composition of tissue-resident monocyte-lineage cells reveal functional heterogeneity during inflammatory arthritis.

ABSTRACT: Tissue-resident monocyte-lineage cell (TRMC) are an extravascular population distinct from circulating monocytes and synovial macrophages and are critical for the development of inflammatory arthritis. However, the precise identities and origins of TRMC subpopulations remain unclear. Here, we characterize the ontogeny of TRMC, which are comprised of bone-marrow (BM)-derived and an embryonic, long-lived population. Furthermore, we identified three TRMC subpopulations, distinguished by expression of TIM4, CX3CR1, and MHCII. Clodronate-laden liposome reduces the number of TRMC but does not impact the proportions or transcriptional profile of TRMC subpopulations at 7 days post administration. TIM4⁺CX3CR1⁺ and TIM4₊ TRMC represent long-lived population, whereas

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12262398 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature