MiRNA-Mediated Regulation of Gene Expression During Early Activation in Jurkat Cells.

ABSTRACT:

Background

T cell activation induces substantial changes in gene expression by rapidly increasing transcription and translation. Additionally, microRNAs play a crucial role in regulating protein expression in T cell physiology, adding a layer of complexity by fine-tuning protein levels. While various miRNAs have been implicated in T cell function, a systematic analysis of differentially expressed miRNAs during early T cell activation and identification of their mRNA targets remains mostly unknown.

Results

We investigated dynamic changes in global gene expression during early T cell activation using a multi-omics approach combining small RNA-seq, mRNA-seq and ribosome profiling. Our results show that most differential expression changes occur by 5 hours postactivation, with t

SUBMITTER: Mukherjee P 

PROVIDER: S-EPMC12262402 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature