Thymic DC2 are heterogenous and include a novel population of transitional dendritic cells.

ABSTRACT: Myeloid cells, including dendritic cells (DCs) and macrophages, are essential for establishing central tolerance in the thymus by promoting T cell clonal deletion and regulatory T cell (Treg) generation. Previous studies suggest that the thymic DC pool consists of plasmacytoid DC (pDC), XCR1⁺ DC1 and SIRPα⁺ DC2. Yet the precise origin, development, and homeostasis, particularly of DC2, remain unresolved. Using single-cell transcriptomics and lineage-defining mouse models we identify nine major populations of thymic myeloid cells and describe their lineage identities. What was previously considered to be "DC2" is actually composed of 4 distinct cell lineages. Amongst these are monocyte-derived DCs (moDC) and monocyte derived macrophages (moMac), which are dependent on

SUBMITTER: Voboril M 

PROVIDER: S-EPMC12262426 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature