Item recognition is associated with gut microbiota composition in healthy humans.

ABSTRACT: Murine studies show that the gut microbiota - the collection of the microbes residing in the large intestine - affects memory performance in the host. However, whether commensal gut bacteria are linked to human episodic memory remains unknown. Here, we investigated whether individual differences in episodic memory performance were associated with differences in the indigenous gut microbiota composition between individuals. We show that greater gut microbiota alpha diversity was associated with better item recognition and that gut microbiota dissimilarity index (beta diversity) between participants was associated with differences in their performance. Finally, our results suggest that Prevotella copri might play a role in the relationship between gut microbiota and human item recogni

SUBMITTER: Oyarzun JP 

PROVIDER: S-EPMC12262429 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature