Lipid-Driven Alignment and Binding of p7 Dimers in Early Oligomer Assembly.

ABSTRACT: Proteins engage in interactions with lipid membranes to facilitate important cellular processes that form the basis of healthy or sick biological conditions. Transmembrane proteins such as ion channels are often made up of bound monomers that engage in specific contacts within the bilayer. However, molecular mechanistic information related to how these channel structures form is scarce. Understanding the role of lipids in driving this process have the potential to close knowledge gaps regarding the assembly behavior of oligomeric proteins which are often clinical targets for disease treatment. Using the hepatitis C virus p7 hexamer as a case study, this work focuses on characterizing the interactions that dictate the beginnings of dimerization using molecular dynamics simulations. Results

SUBMITTER: Campbell O 

PROVIDER: S-EPMC12262441 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature