Senescence-Associated Chromatin Rewiring Promotes Inflammation and Transposable Element Activation.

ABSTRACT: Cellular senescence is a stable form of cell cycle arrest that contributes to aging and age-associated diseases through the secretion of inflammatory factors collectively known as the senescence-associated secretory phenotype (SASP). While senescence is driven by transcriptional and epigenetic changes, the contribution of higher-order genome organization remains poorly defined. Here, we present the highest-resolution Hi-C maps (~3 kb) to date of proliferating, quiescent, and replicative senescent (RS) human fibroblasts, enabling a comprehensive analysis of 3D genome architecture during senescence. Our analyses reveal widespread senescence-associated remodeling of chromatin architecture, including extensive compartment and subcompartment switching toward transcriptionally active states, and

SUBMITTER: Dalgarno A 

PROVIDER: S-EPMC12262444 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature